Wei Jia
The University of Hong Kong

Wei Jia

賈偉

Chair Professor

Vivian Taam Wong Professor in Integrative Medicine

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine

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Years Experience

Biography

Professor Wei Jia is an internationally renowned scientist and a pioneer in the fields of metabolomics, gut microbiome research, and systems pharmacology. At the age of 36, he achieved the rank of full professor and has since accumulated over 30 years of experience leading interdisciplinary research programs in both academic and industrial settings.

His research focuses on unraveling the intricate molecular mechanisms that connect metabolic disruptions in gut microbial-host co-metabolism to the development of metabolic disorders and gastrointestinal cancer. His laboratory operates a world-class metabolomics platform that quantitatively profiles endogenous small-molecule metabolites and trace elements from various biological specimens using advanced LC-MS/MS and GC-MS technologies.

Professor Jia has made groundbreaking discoveries in bile acid metabolism and gut-brain axis interactions. His work has identified novel microbial metabolites that serve as signaling molecules affecting host metabolic health, with important implications for understanding and treating conditions such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, and Alzheimer's disease.

His research on the interaction between melamine in infant formula and childhood gut bacteria, leading to kidney toxicity, was selected as one of Science magazine's "Top Ten Scientific Breakthroughs" in 2013—a testament to the translational impact of his work on public health.

Research Interests

Gut Microbiota-Host Co-metabolism
Bile Acid Signaling & Metabolism
Metabolomics & Precision Medicine
Cancer Metabolism
Systems Pharmacology
Traditional Chinese Medicine

Research Statement

Our laboratory focuses on understanding the intricate molecular mechanisms that connect metabolic disruptions in gut microbial-host co-metabolism to the development of metabolic disorders and gastrointestinal cancer. We employ cutting-edge metabolomics platforms combined with metagenomics, systems biology, and translational approaches to decode the metabolic dialogue between gut microbes and their host. Our research has made significant contributions to understanding bile acid metabolism and its role in metabolic homeostasis. We have identified novel microbial bile acid modifications and their signaling through FXR and TGR5 receptors, with implications for treating type 2 diabetes, NAFLD, and other metabolic diseases. We are also pioneering research into the gut-brain axis, investigating how microbial metabolites influence neurological function and contribute to conditions such as depression and Alzheimer's disease. Our work bridges basic science discovery with clinical applications, working closely with clinicians to develop metabolomics-based precision medicine strategies.

Professional Positions

2024–Present

Chair Professor, Vivian Taam Wong Professor in Integrative Medicine

The University of Hong Kong

Hong Kong

2019–2024

Chair Professor, Director of Center for Translational Medicine

Hong Kong Baptist University

Hong Kong

2013–2019

Professor, Director of Metabolomics Shared Resource

University of Hawaii Cancer Center

USA

2008–2013

Professor, Founding Director of Center for Translational Biomedical Research

University of North Carolina at Greensboro

USA

2003–2008

Professor, Associate Dean of School of Pharmacy

Shanghai Jiao Tong University

China

2001–2002

Executive Vice Dean, School of Pharmaceutical Sciences

Tianjin University

China

Awards & Honors

Member, Academia Europaea

Physiology & Neuroscience Section

2023

President's Award for Outstanding Performance in Scholarly Work

Hong Kong Baptist University

2023

Highly Cited Chinese Researcher

Elsevier

2023

Highly Cited Chinese Researcher

Elsevier

2022

Highly Cited Chinese Researcher

Elsevier

2021

Highly Cited Chinese Researcher

Elsevier

2020

Highly Cited Chinese Researcher

Elsevier

2019

Natural Science Award

Shanghai Municipal Government

2016

Top Ten Scientific Breakthroughs

Science Magazine

2013

Professional Memberships

Academia Europaea

Member, Physiology & Neuroscience Section

Since 2023

Metabolomics Association of North America

Founding Member

Since 2012

Chinese Pharmacological Society

Founding Member & Standing Director, Analytical Pharmacology Committee

Since 2019

World's Top 2% Scientists

Listed by Stanford University

Editorial Boards

Cell Death & Differentiation

Editorial Board Member

iMeta

Editorial Board Member

Cell Death & Disease

Editorial Board Member

Journal of Ethnopharmacology

Editorial Board Member

Frontiers in Pharmacology

Review Editor

Life Metabolism

Editorial Board Member

Protein & Cell

Editorial Board Member

Gut Microbes

Editorial Board Member

Explore the Research

Browse our complete collection of publications spanning metabolomics, gut microbiome, bile acid metabolism, and systems pharmacology.

Get in Touch

Interested in collaboration, joining the lab, or learning more about our research?

Department of Pharmacology and Pharmacy, The University of Hong Kong