
Wei Jia
賈偉
Chair Professor
Vivian Taam Wong Professor in Integrative Medicine
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine
Biography
Professor Wei Jia is an internationally renowned scientist and a pioneer in the fields of metabolomics, gut microbiome research, and systems pharmacology. At the age of 36, he achieved the rank of full professor and has since accumulated over 30 years of experience leading interdisciplinary research programs in both academic and industrial settings.
His research focuses on unraveling the intricate molecular mechanisms that connect metabolic disruptions in gut microbial-host co-metabolism to the development of metabolic disorders and gastrointestinal cancer. His laboratory operates a world-class metabolomics platform that quantitatively profiles endogenous small-molecule metabolites and trace elements from various biological specimens using advanced LC-MS/MS and GC-MS technologies.
Professor Jia has made groundbreaking discoveries in bile acid metabolism and gut-brain axis interactions. His work has identified novel microbial metabolites that serve as signaling molecules affecting host metabolic health, with important implications for understanding and treating conditions such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, and Alzheimer's disease.
His research on the interaction between melamine in infant formula and childhood gut bacteria, leading to kidney toxicity, was selected as one of Science magazine's "Top Ten Scientific Breakthroughs" in 2013—a testament to the translational impact of his work on public health.
Research Interests
Research Statement
Our laboratory focuses on understanding the intricate molecular mechanisms that connect metabolic disruptions in gut microbial-host co-metabolism to the development of metabolic disorders and gastrointestinal cancer. We employ cutting-edge metabolomics platforms combined with metagenomics, systems biology, and translational approaches to decode the metabolic dialogue between gut microbes and their host. Our research has made significant contributions to understanding bile acid metabolism and its role in metabolic homeostasis. We have identified novel microbial bile acid modifications and their signaling through FXR and TGR5 receptors, with implications for treating type 2 diabetes, NAFLD, and other metabolic diseases. We are also pioneering research into the gut-brain axis, investigating how microbial metabolites influence neurological function and contribute to conditions such as depression and Alzheimer's disease. Our work bridges basic science discovery with clinical applications, working closely with clinicians to develop metabolomics-based precision medicine strategies.
Professional Positions
Chair Professor, Vivian Taam Wong Professor in Integrative Medicine
The University of Hong Kong
Hong Kong
Chair Professor, Director of Center for Translational Medicine
Hong Kong Baptist University
Hong Kong
Professor, Director of Metabolomics Shared Resource
University of Hawaii Cancer Center
USA
Professor, Founding Director of Center for Translational Biomedical Research
University of North Carolina at Greensboro
USA
Professor, Associate Dean of School of Pharmacy
Shanghai Jiao Tong University
China
Executive Vice Dean, School of Pharmaceutical Sciences
Tianjin University
China
Awards & Honors
Member, Academia Europaea
Physiology & Neuroscience Section
President's Award for Outstanding Performance in Scholarly Work
Hong Kong Baptist University
Highly Cited Chinese Researcher
Elsevier
Highly Cited Chinese Researcher
Elsevier
Highly Cited Chinese Researcher
Elsevier
Highly Cited Chinese Researcher
Elsevier
Highly Cited Chinese Researcher
Elsevier
Natural Science Award
Shanghai Municipal Government
Top Ten Scientific Breakthroughs
Science Magazine
Professional Memberships
Academia Europaea
Member, Physiology & Neuroscience Section
Since 2023
Metabolomics Association of North America
Founding Member
Since 2012
Chinese Pharmacological Society
Founding Member & Standing Director, Analytical Pharmacology Committee
Since 2019
World's Top 2% Scientists
Listed by Stanford University
Editorial Boards
Cell Death & Differentiation
Editorial Board Member
iMeta
Editorial Board Member
Cell Death & Disease
Editorial Board Member
Journal of Ethnopharmacology
Editorial Board Member
Frontiers in Pharmacology
Review Editor
Life Metabolism
Editorial Board Member
Protein & Cell
Editorial Board Member
Gut Microbes
Editorial Board Member
Explore the Research
Browse our complete collection of publications spanning metabolomics, gut microbiome, bile acid metabolism, and systems pharmacology.
Get in Touch
Interested in collaboration, joining the lab, or learning more about our research?
Department of Pharmacology and Pharmacy, The University of Hong Kong