The University of Hong Kong

Wei Jia Lab

We investigate the intricate molecular mechanisms connecting metabolic disruptions in gut microbial-host co-metabolism to the development of metabolic disorders and gastrointestinal cancer.

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Led by

Professor Wei Jia(賈偉)

Chair Professor, Vivian Taam Wong Professor in Integrative Medicine

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Our Focus

Research Areas

We investigate the molecular mechanisms connecting gut microbiota to human health and disease, developing novel therapeutic and diagnostic approaches.

Gut Microbiota-Host Co-metabolism

Decoding the metabolic dialogue between gut microbes and host

LC-MS/MS MetabolomicsMetagenomicsGnotobiotic Mouse Models+1
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BA

Bile Acid Signaling & Metabolism

Bile acids as master regulators of metabolic health

Targeted Bile Acid ProfilingNuclear Receptor AssaysHepatocyte Models+1
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Metabolomics in Cancer Research

Metabolic signatures for cancer diagnosis and therapy

Untargeted MetabolomicsStable Isotope TracingTumor Organoids+1
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Systems Pharmacology

Network approaches to drug discovery and personalized medicine

Network PharmacologyPharmacometabolomicsComputational Drug Discovery+1
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Selected Work

Featured Publications

Highlights from our recent research published in leading scientific journals.

Cell Metabolism2025Featured

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology

Li R, Li Y, Jiang K, Zhang L, et al.

Revealed functional diversity of arginine metabolism in physiology and pathology using novel metabolic approaches.

arginine metabolismmetabolomicsphysiologypathology
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Protein & Cell2025reviewFeatured

Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics

Kuang J, Zheng X, Jia W

Comprehensive review on regional gut microbial distribution and its therapeutic implications.

gut microbiomeregional distributiontherapeuticsreview
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Cell Metabolism2024Featured

Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity

Zhao M, Ren Z, Zhao A, Tang Y, et al.

Discovered gut bacteria-derived homovanillic acid alleviates depression by protecting synaptic integrity (78 citations).

gut-brain axisdepressionhomovanillic acidsynaptic integrity
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Cell Reports Medicine2024Featured

Increased intestinal bile acid absorption contributes to age-related cognitive impairment

Ren Z, Zhao L, Zhao M, Bao T, et al.

Revealed increased intestinal bile acid absorption contributes to age-related cognitive decline (37 citations).

bile acidscognitive impairmentaginggut-brain axis
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Nature Communications2024Featured

Metabolic phenotyping reveals an emerging role of ammonia abnormality in Alzheimer's disease

Chen T, Pan F, Huang Q, Xie G, et al.

Discovered emerging role of ammonia abnormality in Alzheimer's disease (31 citations).

Alzheimer's diseaseammoniametabolomicsneurodegeneration
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Science China Life Sciences2024reviewFeatured

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

Jia W, Li Y, Cheung KCP, Zheng X

Comprehensive review on bile acid signaling in metabolic and immune regulation (128 citations).

bile acidsmetabolismimmunologyhomeostasis
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